https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Hypothesis-driven genome-wide association studies provide novel insights into genetics of reading disabilities https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51039 -2, threshold = 2.5 × 10-2). For the GenLang Cohort (n = 26,558), SNPs in DOCK7 and CDH4 showed significant association for the NM/AG hypothesis (sFDR q = 1.02 × 10-2). To make the GenLang dataset more similar to Toronto, we repeated the analysis restricting to samples selected for reading/language deficits (n = 4152). In this GenLang selected subset, we found significant association for a locus intergenic between BTG3-C21orf91 for both hypotheses (sFDR q < 9.00 × 10-4). This study contributes candidate loci to the genetics of word reading. Data also suggest that, although different variants may be involved, alleles implicated in ASD risk may be found in the same genes as those implicated in word reading. This finding is limited to the Toronto sample suggesting that ascertainment influences genetic associations.]]> Wed 16 Aug 2023 10:23:40 AEST ]]> Genome-wide analyses of vocabulary size in infancy and toddlerhood: Associations with Attention-Deficit/Hyperactivity Disorder, literacy, and cognition-related traits https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:56072 Mon 29 Jul 2024 15:31:10 AEST ]]>